Tìm thấy 12954 | Hiện thị tối đa 200
Bài báo
Establishment of gene-edited pigs expressing human blood coagulation factor VII and albumin for bioartificial liver use.
Li L, Meng H, Zou Q, Zhang J, Cai L, Yang B, Weng J, Lai L, Yang H, Gao Y.
Journal of gastroenterology and hepatology. 2019 Mar 18; | doi: 10.1111/jgh.14666 | PMID: 30884543
Tóm tắt Chức năng
The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events.
Janssen JM, Chen X, Liu J, Gonçalves MAFV.
Molecular therapy. Nucleic acids. 2019 Feb 20;16:141-154 | doi: 10.1016/j.omtn.2019.02.009 | PMID: 30884291
Tóm tắt Chức năng
Applications of CRISPR systems in respiratory health: Entering a new 'red pen' era in genome editing.
Moses C, Kaur P.
Respirology (Carlton, Vic.). 2019 Mar 18; | doi: 10.1111/resp.13527 | PMID: 30883991
Tóm tắt Chức năng
Recruitment of specific flavonoid B-ring hydroxylases for two independent biosynthesis pathways of flavone-derived metabolites in grasses.
Lam PY, Lui AC, Yamamura M, Wang L, Takeda Y, Suzuki S, Liu H, Zhu FY, Chen MX, Zhang J, Umezawa T, Tobimatsu Y, Lo C.
The New phytologist. 2019 Mar 18; | doi: 10.1111/nph.15795 | PMID: 30883799
Tóm tắt Chức năng
Reduced Apoptosis in Chinese Hamster Ovary Cells via Optimized CRISPR Interference.
Xiong K, Marquart KF, Karottki KJC, Li S, Shamie I, Lee JS, Gerling S, Yeo NC, Chavez A, Lee GM, Lewis NE, Kildegaard HF.
Biotechnology and bioengineering. 2019 Mar 18; | doi: 10.1002/bit.26969 | PMID: 30883679
Tóm tắt Chức năng
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
Kleene SJ, Siroky BJ, Landero-Figueroa JA, Dixon BP, Pachciarz NW, Lu L, Kleene NK.
PloS one. 2019;14(3):e0214053 | doi: 10.1371/journal.pone.0214053 | PMID: 30883612
Tóm tắt Chức năng
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases.
Kim D, Luk K, Wolfe SA, Kim JS.
Annual review of biochemistry. 2019 Mar 18; | doi: 10.1146/annurev-biochem-013118-111730 | PMID: 30883196
Tóm tắt Chức năng
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR.
Rankin CR, Treger J, Faure-Kumar E, Benhammou J, Anisman-Posner D, Bollinger AE, Pothoulakis C, Padua DM.
Journal of visualized experiments : JoVE. 2019 Mar 1;(145) | doi: 10.3791/59233 | PMID: 30882798
Tóm tắt Chức năng
Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution.
Lee J, Jung MH, Jeong E, Lee JK.
Journal of visualized experiments : JoVE. 2019 Feb 26;(144) | doi: 10.3791/59202 | PMID: 30882797
Tóm tắt Chức năng
Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique.
Lu ZJ, Yu Q, Zhou SH, Fan J, Shen LF, Bao YY, Wu TT, Zhou ML, Huang YP.
Cancer management and research. 2019;11:2087-2096 | doi: 10.2147/CMAR.S183859 | PMID: 30881132 | PMC: PMC6413817
Tóm tắt Chức năng
Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells.
Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A.
Cell cycle (Georgetown, Tex.). 2019 Mar 17; | doi: 10.1080/15384101.2019.1593650 | PMID: 30880567
Tóm tắt Chức năng
Tracing MYC Expression for Small Molecule Discovery.
Steinberger J, Robert F, Hallé M, Williams DE, Cencic R, Sawhney N, Pelletier D, Williams P, Igarashi Y, Porco JA Jr, Rodriguez AD, Kopp B, Bachmann B, Andersen RJ, Pelletier J.
Cell chemical biology. 2019 Feb 21; | doi: 10.1016/j.chembiol.2019.02.007 | PMID: 30880156
Tóm tắt Chức năng
Understanding the mechanistic basis of non-coding RNA through molecular dynamics simulations.
Palermo G, Casalino L, Magistrato A, Andrew McCammon J.
Journal of structural biology. 2019 Mar 14; | doi: 10.1016/j.jsb.2019.03.004 | PMID: 30880083
Tóm tắt Chức năng
CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors.
Chen Z, Cai X, Li M, Yan L, Wu L, Wang X, Tang N.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1):799-807 | doi: 10.1080/14756366.2019.1587416 | PMID: 30879343
Tóm tắt Chức năng
Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease.
Luo J, Padhi P, Jin H, Anantharam V, Zenitsky G, Wang Q, Willette AA, Kanthasamy A, Kanthasamy AG.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2019 Mar 16; | doi: 10.1007/s11481-019-09844-3 | PMID: 30879240
Tóm tắt Chức năng
Coupling ssDNA recombineering with CRISPR-Cas9 for Escherichia coli DnaG mutations.
Li J, Sun J, Gao X, Wu Z, Shang G.
Applied microbiology and biotechnology. 2019 Mar 16; | doi: 10.1007/s00253-019-09744-9 | PMID: 30879090
Tóm tắt Chức năng
Modeling Pancreatic Cancer through Somatic Editing with AAV.
Curiel-GarcÍa A, Olive KP.
Trends in molecular medicine. 2019 Mar 13; | doi: 10.1016/j.molmed.2019.02.012 | PMID: 30878400
Tóm tắt Chức năng
Application of the CRISPR/Cas System for Generation of Pathogen-Resistant Plants.
Makarova SS, Khromov AV, Spechenkova NA, Taliansky ME, Kalinina NO.
Biochemistry. Biokhimiia. 2018 Dec;83(12):1552-1562 | doi: 10.1134/S0006297918120131 | PMID: 30878030
Tóm tắt Chức năng
Colorimetric detection of nucleic acid sequences in plant pathogens based on CRISPR/Cas9 triggered signal amplification.
Chang W, Liu W, Liu Y, Zhan F, Chen H, Lei H, Liu Y.
Mikrochimica acta. 2019 Mar 15;186(4):243 | doi: 10.1007/s00604-019-3348-2 | PMID: 30877395
Tóm tắt Chức năng
Application of the CRISPR/Cas system for genome editing in microalgae.
Zhang YT, Jiang JY, Shi TQ, Sun XM, Zhao QY, Huang H, Ren LJ.
Applied microbiology and biotechnology. 2019 Mar 15; | doi: 10.1007/s00253-019-09726-x | PMID: 30877356
Tóm tắt Chức năng
Did a permissive scientific culture encourage the 'CRISPR babies' experiment?
Dickenson D, Darnovsky M.
Nature biotechnology. 2019 Mar 15; | doi: 10.1038/s41587-019-0077-3 | PMID: 30877281
Tóm tắt Chức năng
Review of the scientific evolution of gene therapy for the treatment of homozygous familial hypercholesterolaemia: past, present and future perspectives.
Rodriguez-Calvo R, Masana L.
Journal of medical genetics. 2019 Mar 15; | doi: 10.1136/jmedgenet-2018-105713 | PMID: 30877235
Tóm tắt Chức năng
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection.
Albers JJ, Ammon T, Gosmann D, Audehm S, Thoene S, Winter C, Secci R, Wolf A, Stelzl A, Steiger K, Ruland J, Bassermann F, Kupatt C, Anton M, Krackhardt AM.
Life science alliance. 2019 Apr;2(2) | doi: 10.26508/lsa.201900367 | PMID: 30877233
Tóm tắt Chức năng
The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α.
Dimova EY, Jakupovic M, Kubaichuk K, Mennerich D, Chi TF, Tamanini F, Oklejewicz M, Hänig J, Byts N, Mäkelä KA, Herzig KH, Koivunen P, Chaves I, van der Horst G, Kietzmann T.
iScience. 2019 Mar 1;13:284-304 | doi: 10.1016/j.isci.2019.02.027 | PMID: 30875610
Tóm tắt Chức năng
Chimeric antigen receptor T cell therapy and other therapeutics for malignancies: Combination and opportunity.
Wang L, Yao R, Zhang L, Fan C, Ma L, Liu J.
International immunopharmacology. 2019 Mar 12;70:498-503 | doi: 10.1016/j.intimp.2019.01.010 | PMID: 30875561
Tóm tắt Chức năng
The dynamin-like protein Fzl promotes thylakoid fusion and resistance to light stress in Chlamydomonas reinhardtii.
Findinier J, Delevoye C, Cohen MM.
PLoS genetics. 2019 Mar 15;15(3):e1008047 | doi: 10.1371/journal.pgen.1008047 | PMID: 30875368
Tóm tắt Chức năng
Systematic analysis of Type I-E Escherichia coli CRISPR-Cas PAM sequences ability to promote interference and primed adaptation.
Musharova O, Sitnik V, Vlot M, Savitskaya E, Datsenko KA, Krivoy A, Fedorov I, Semenova E, Brouns SJJ, Severinov K.
Molecular microbiology. 2019 Mar 15; | doi: 10.1111/mmi.14237 | PMID: 30875129
Tóm tắt Chức năng
CRISPR-Cas, a highly effective tool for genome editing in Clostridium saccharoperbutylacetonicum N1-4(HMT).
Atmadjaja AN, Holby V, Harding AJ, Krabben P, Smith HK, Jenkinson ER.
FEMS microbiology letters. 2019 Mar 15; | doi: 10.1093/femsle/fnz059 | PMID: 30874768
Tóm tắt Chức năng
High-fidelity and rapid quantification of miRNA combining crRNA programmability and CRISPR/Cas13a trans cleavage activity.
Shan Y, Zhou X, Huang R, Xing D.
Analytical chemistry. 2019 Mar 15; | doi: 10.1021/acs.analchem.9b00073 | PMID: 30873832
Tóm tắt Chức năng
A Practical Guide to Genome Editing Using Targeted Nuclease Technologies.
Porter SN, Levine RM, Pruett-Miller SM.
Comprehensive Physiology. 2019 Mar 14;9(2):665-714 | doi: 10.1002/cphy.c180022 | PMID: 30873595
Tóm tắt Chức năng
PMEPA1/TMEPAI knockout impairs tumor growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth.
Abdelaziz M, Watanabe Y, Kato M.
Journal of biochemistry. 2019 Mar 14; | doi: 10.1093/jb/mvz022 | PMID: 30873542
Tóm tắt Chức năng
Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation.
Lenz DR, Gunewardene N, Abdul-Aziz DE, Wang Q, Gibson TM, Edge ASB.
Frontiers in cell and developmental biology. 2019;7:14 | doi: 10.3389/fcell.2019.00014 | PMID: 30873406 | PMC: PMC6401656
Tóm tắt Chức năng
Translating Human Cancer Sequences Into Personalized Porcine Cancer Models.
Xu C, Wu S, Schook LB, Schachtschneider KM.
Frontiers in oncology. 2019;9:105 | doi: 10.3389/fonc.2019.00105 | PMID: 30873383 | PMC: PMC6401626
Tóm tắt Chức năng
Targeting uPAR by CRISPR/Cas9 System Attenuates Cancer Malignancy and Multidrug Resistance.
Wang K, Xing ZH, Jiang QW, Yang Y, Huang JR, Yuan ML, Wei MN, Li Y, Wang ST, Liu K, Shi Z.
Frontiers in oncology. 2019;9:80 | doi: 10.3389/fonc.2019.00080 | PMID: 30873379 | PMC: PMC6400983
Tóm tắt Chức năng
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Uehara T, Suzuki H, Okamoto N, Kondoh T, Ahmad A, O'Connor BC, Yoshina S, Mitani S, Kosaki K, Takenouchi T.
Scientific reports. 2019 Mar 14;9(1):4418 | doi: 10.1038/s41598-019-40988-7 | PMID: 30872706
Tóm tắt Chức năng
Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation.
Takimoto A, Kokubu C, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y, Shukunami C.
Scientific reports. 2019 Mar 14;9(1):4605 | doi: 10.1038/s41598-019-40810-4 | PMID: 30872687
Tóm tắt Chức năng
A simple genotyping method to detect small CRISPR-Cas9 induced indels by agarose gel electrophoresis.
Bhattacharya D, Van Meir EG.
Scientific reports. 2019 Mar 14;9(1):4437 | doi: 10.1038/s41598-019-39950-4 | PMID: 30872606
Tóm tắt Chức năng
N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA.
Science (New York, N.Y.). 2019 Mar 14; | doi: 10.1126/science.aau1208 | PMID: 30872531
Tóm tắt Chức năng
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.
Rollins MF, Chowdhury S, Carter J, Golden SM, Miettinen HM, Santiago-Frangos A, Faith D, Lawrence CM, Lander GC, Wiedenheft B.
Molecular cell. 2019 Mar 1; | doi: 10.1016/j.molcel.2019.02.001 | PMID: 30872121
Tóm tắt Chức năng
Targeted in vivo epigenome editing of H3K27me3.
Fukushima HS, Takeda H, Nakamura R.
Epigenetics & chromatin. 2019 Mar 13;12(1):17 | doi: 10.1186/s13072-019-0263-z | PMID: 30871638
Tóm tắt Chức năng
Sigma-1 receptor ablation impairs autophagosome clearance.
Yang H, Shen H, Li J, Guo LW.
Autophagy. 2019 Mar 14;:1-19 | doi: 10.1080/15548627.2019.1586248 | PMID: 30871407
Tóm tắt Chức năng
The Impact of HIV-1 Genetic Diversity on CRISPR-Cas9 Antiviral Activity and Viral Escape.
Darcis G, Binda CS, Klaver B, Herrera-Carrillo E, Berkhout B, Das AT.
Viruses. 2019 Mar 13;11(3) | doi: 10.3390/v11030255 | PMID: 30871200
Tóm tắt Chức năng
Efficient Editing of the Nuclear APT Reporter Gene in Chlamydomonas reinhardtii via Expression of a CRISPR-Cas9 Module.
Guzmán-Zapata D, Sandoval-Vargas JM, Macedo-Osorio KS, Salgado-Manjarrez E, Castrejón-Flores JL, Oliver-Salvador MDC, Durán-Figueroa NV, Nogué F, Badillo-Corona JA.
International journal of molecular sciences. 2019 Mar 12;20(5) | doi: 10.3390/ijms20051247 | PMID: 30871076
Tóm tắt Chức năng
Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression.
Ashley CL, Abendroth A, McSharry BP, Slobedman B.
Viruses. 2019 Mar 12;11(3) | doi: 10.3390/v11030246 | PMID: 30871003
Tóm tắt Chức năng
Collateral damage and CRISPR genome editing.
Thomas M, Burgio G, Adams DJ, Iyer V.
PLoS genetics. 2019 Mar;15(3):e1007994 | doi: 10.1371/journal.pgen.1007994 | PMID: 30870431
Tóm tắt Chức năng
TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance.
Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM.
JCI insight. 2019 Mar 14;5 | doi: 10.1172/jci.insight.126749 | PMID: 30870143
Tóm tắt Chức năng
The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation.
Liu YS, Wang LF, Cheng XS, Huo YN, Ouyang XM, Liang LY, Lin Y, Wu JF, Ren JL, Guleng B.
Journal of cellular and molecular medicine. 2019 Mar 14; | doi: 10.1111/jcmm.14236 | PMID: 30869196
Tóm tắt Chức năng
The Klf6 Super Enhancer Modulates Cell Proliferation via MiR-1301 in Human Hepatoma Cells.
Ri K, Kim C, Pak C, Ri P, Om H.
MicroRNA (Shariqah, United Arab Emirates). 2019 Mar 14; | doi: 10.2174/2211536608666190314122725 | PMID: 30868974
Tóm tắt Chức năng
Advances In Research On Genome Editing Crispr-Cas9 Technology.
Shah SZ, Rehman A, Nasir H, Asif A, Tufail B, Usama M, Jabbar B.
Journal of Ayub Medical College, Abbottabad : JAMC. 2019 Jan-Mar;31(1):108-122 | PMID: 30868795
Tóm tắt Chức năng
Genome Editing by CRISPR/Cas9 in Trypanosoma cruzi.
Lander N, Chiurillo MA, Docampo R.
Methods in molecular biology (Clifton, N.J.). 2019;1955:61-76 | doi: 10.1007/978-1-4939-9148-8_5 | PMID: 30868519
Tóm tắt Chức năng
Impact of a bathing tradition on shared gut microbe among Japanese families.
Odamaki T, Bottacini F, Mitsuyama E, Yoshida K, Kato K, Xiao JZ, van Sinderen D.
Scientific reports. 2019 Mar 13;9(1):4380 | doi: 10.1038/s41598-019-40938-3 | PMID: 30867524
Tóm tắt Chức năng
An essential role for miRNA167 in maternal control of embryonic and seed development.
Yao X, Chen J, Zhou J, Yu H, Ge C, Zhang M, Gao X, Dai X, Yang ZN, Zhao Y.
Plant physiology. 2019 Mar 13; | doi: 10.1104/pp.19.00127 | PMID: 30867333
Tóm tắt Chức năng
Plasmid-Based CRISPR-Cas9 Gene Editing in Multiple Candida Species.
Lombardi L, Oliveira-Pacheco J, Butler G.
mSphere. 2019 Mar 13;4(2) | doi: 10.1128/mSphere.00125-19 | PMID: 30867327
Tóm tắt Chức năng
Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation.
Feng YY, Tang M, Suzuki M, Gunasekara C, Anbe Y, Hiraoka Y, Liu J, Grasberger H, Ohkita M, Matsumura Y, Wang JY, Tsubata T.
Journal of immunology (Baltimore, Md. : 1950). 2019 Mar 13; | doi: 10.4049/jimmunol.1800443 | PMID: 30867238
Tóm tắt Chức năng
Integrated analyses of phenotype and quantitative proteome of CMTM4 deficient mice reveal its association with male fertility.
Liu F, Liu XX, Liu X, Li T, Zhu P, Liu Z, Xue H, Wang W Jr, Yang X, Liu J, Han W.
Molecular & cellular proteomics : MCP. 2019 Mar 13; | doi: 10.1074/mcp.RA119.001416 | PMID: 30867229
Tóm tắt Chức năng
Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements.
Thormann V, Glaser LV, Rothkegel MC, Borschiwer M, Bothe M, Fuchs A, Meijsing SH.
Life science alliance. 2019 Apr;2(2) | doi: 10.26508/lsa.201800283 | PMID: 30867223
Tóm tắt Chức năng
GRIBCG: a software for selection of sgRNAs in the design of balancer chromosomes.
Merritt BB, Cheung LS.
BMC bioinformatics. 2019 Mar 12;20(1):122 | doi: 10.1186/s12859-019-2712-x | PMID: 30866794
Tóm tắt Chức năng
GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression.
Santolla MF, Vivacqua A, Lappano R, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Brunetti G, Miglietta AM, Belfiore A, Maggiolini M.
Cells. 2019 Mar 7;8(3) | doi: 10.3390/cells8030223 | PMID: 30866584
Tóm tắt Chức năng
Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.
Fang Z, Weng C, Li H, Tao R, Mai W, Liu X, Lu L, Lai S, Duan Q, Alvarez C, Arvan P, Wynshaw-Boris A, Li Y, Pei Y, Jin F, Li Y.
Cell reports. 2019 Mar 12;26(11):3132-3144.e7 | doi: 10.1016/j.celrep.2019.02.043 | PMID: 30865899
Tóm tắt Chức năng
An expanded synthetic biology toolkit for gene expression control in Acetobacteraceae.
Teh MY, Ooi KH, Teo SXD, Mansoor MEB, Lim WZS, Tan MH.
ACS synthetic biology. 2019 Mar 13; | doi: 10.1021/acssynbio.8b00168 | PMID: 30865830
Tóm tắt Chức năng
Mutations of Kluyveromyces lactis dolichol kinase enhances secretion of recombinant proteins.
Ziogiene D, Valaviciute M, Norkiene M, Timinskas A, Gedvilaite A.
FEMS yeast research. 2019 Mar 13; | doi: 10.1093/femsyr/foz024 | PMID: 30865773
Tóm tắt Chức năng
Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2.
Zhou B, Ho SS, Greer SU, Spies N, Bell JM, Zhang X, Zhu X, Arthur JG, Byeon S, Pattni R, Saha I, Huang Y, Song G, Perrin D, Wong WH, Ji HP, Abyzov A, Urban AE.
Nucleic acids research. 2019 Mar 13; | doi: 10.1093/nar/gkz169 | PMID: 30864654
Tóm tắt Chức năng
A use/disuse paradigm for CRISPR-Cas systems.
Veigl SJ.
Biology & philosophy. 2019;34(1):13 | doi: 10.1007/s10539-018-9661-z | PMID: 30864562 | PMC: PMC6380192
Tóm tắt Chức năng
Therapeutic gene editing in haematological disorders with CRISPR/Cas9.
Jensen TI, Axelgaard E, Bak RO.
British journal of haematology. 2019 Mar 12; | doi: 10.1111/bjh.15851 | PMID: 30864164
Tóm tắt Chức năng
Increasing the efficiency of CRISPR/Cas9-based gene editing by suppressing RNAi in plants.
Wang X, Lu J, Lao K, Wang S, Mo X, Xu X, Chen X, Mo B.
Science China. Life sciences. 2019 Mar 13; | doi: 10.1007/s11427-019-9514-9 | PMID: 30863962
Tóm tắt Chức năng
A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation.
Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams D, Ianov L, Day JJ.
eNeuro. 2019 Jan-Feb;6(1) | doi: 10.1523/ENEURO.0495-18.2019 | PMID: 30863790 | PMC: PMC6412672
Tóm tắt Chức năng
Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma.
Petersen CT, Krenciute G.
Frontiers in oncology. 2019;9:69 | doi: 10.3389/fonc.2019.00069 | PMID: 30863720 | PMC: PMC6399104
Tóm tắt Chức năng
POPX2 is a novel LATS phosphatase that regulates the Hippo pathway.
Rahmat MB, Zhang S, Koh CG.
Oncotarget. 2019 Feb 19;10(15):1525-1538 | doi: 10.18632/oncotarget.26689 | PMID: 30863499 | PMC: PMC6407677
Tóm tắt Chức năng
Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss.
Girotto G, Morgan A, Krishnamoorthy N, Cocca M, Brumat M, Bassani S, La Bianca M, Di Stazio M, Gasparini P.
Frontiers in genetics. 2019;10:142 | doi: 10.3389/fgene.2019.00142 | PMID: 30863428 | PMC: PMC6399162
Tóm tắt Chức năng
Dynamin Binding Protein Is Required for Xenopus laevis Kidney Development.
DeLay BD, Baldwin TA, Miller RK.
Frontiers in physiology. 2019;10:143 | doi: 10.3389/fphys.2019.00143 | PMID: 30863317 | PMC: PMC6399408
Tóm tắt Chức năng
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.
Zheng Y, Ramsamooj S, Li Q, Johnson JL, Yaron TM, Sharra K, Cantley LC.
Scientific reports. 2019 Mar 12;9(1):4190 | doi: 10.1038/s41598-019-40950-7 | PMID: 30862944
Tóm tắt Chức năng A Versatile and High-throughput Analysis Program for CRISPR-based Genome Editing.
Connelly JP, Pruett-Miller SM.
Scientific reports. 2019 Mar 12;9(1):4194 | doi: 10.1038/s41598-019-40896-w | PMID: 30862905
Tóm tắt Chức năng
Spindle assembly checkpoint inhibition can resensitize p53-null stem cells to cancer chemotherapy.
Liu C, Banister CE, Buckhaults PJ.
Cancer research. 2019 Mar 12; | doi: 10.1158/0008-5472.CAN-18-3024 | PMID: 30862715
Tóm tắt Chức năng
CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Poondla N, Chandrasekaran AP, Heese K, Kim KS, Ramakrishna S.
Biochemical and biophysical research communications. 2019 Mar 9; | doi: 10.1016/j.bbrc.2019.03.018 | PMID: 30862357
Tóm tắt Chức năng
Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1.
Soubeyrand S, Nikpay M, Turner A, Dang AT, Herfkens M, Lau P, McPherson R.
Atherosclerosis. 2019 Feb 22;284:11-17 | doi: 10.1016/j.atherosclerosis.2019.02.012 | PMID: 30861420
Tóm tắt Chức năng
Citrullinated Inhibitor of DNA Binding 1 is a Novel Autoantigen in Rheumatoid Arthritis.
Ohara RA, Edhayan G, Rasmussen SM, Isozaki T, Remmer HA, Lanigan TM, Campbell PL, Urquhart AG, Lawton JN, Chung KC, Fox DA, Ruth JH.
Arthritis & rheumatology (Hoboken, N.J.). 2019 Mar 12; | doi: 10.1002/art.40886 | PMID: 30861322
Tóm tắt Chức năng
Accelerated genome engineering of Pseudomonas putida by I-SceI-mediated recombination and CRISPR-Cas9 counterselection.
Wirth NT, Kozaeva E, Nikel PI.
Microbial biotechnology. 2019 Mar 12; | doi: 10.1111/1751-7915.13396 | PMID: 30861315
Tóm tắt Chức năng
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, Ward A, McSteen B, Labella KM, Keskula P, Tracy A, Connor C, Clinton CM, Church AJ, Crompton BD, Janeway KA, Van Hare B, Sandak D, Gjoerup O, Bandopadhayay P, Clemons PA, Schreiber SL, Root DE, Gokhale PC, Chi SN, Mullen EA, Roberts CW, Kadoch C, Beroukhim R, Ligon KL, Boehm JS, Hahn WC.
eLife. 2019 Mar 12;8 | doi: 10.7554/eLife.44161 | PMID: 30860482
Tóm tắt Chức năng
Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-Cas13a.
Qin P, Park M, Alfson K, Tamhankar M, Carrion R, Patterson J, Griffiths A, He Q, Yildiz A, Mathies RA, Du K.
ACS sensors. 2019 Mar 12; | doi: 10.1021/acssensors.9b00239 | PMID: 30860365
Tóm tắt Chức năng
Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation.
Baechler BL, Bloemberg D, Quadrilatero J.
Autophagy. 2019 Mar 12; | doi: 10.1080/15548627.2019.1591672 | PMID: 30859901
Tóm tắt Chức năng
Recent advancements in gene and stem cell based treatment modalities: potential applications in noise induced hearing loss.
Eshraghi AA, Jung HD, Mittal R.
Anatomical record (Hoboken, N.J. : 2007). 2019 Mar 11; | doi: 10.1002/ar.24107 | PMID: 30859735
Tóm tắt Chức năng
Establishment of CRISPR/Cas9-Mediated Knock-in System for Porcine Cells with High Efficiency.
Zhang J, Zhu Z, Yue W, Li J, Chen Q, Yan Y, Lei A, Hua J.
Applied biochemistry and biotechnology. 2019 Mar 12; | doi: 10.1007/s12010-019-02984-5 | PMID: 30859452
Tóm tắt Chức năng
Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro.
Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, Becker D, Dow LE, Marhenke S, Woller N, Unger K, Schirmacher P, Manns MP, Marquardt JU, Vogel A, Saborowski M.
Hepatology communications. 2019 Mar;3(3):423-436 | doi: 10.1002/hep4.1312 | PMID: 30859153 | PMC: PMC6396372
Tóm tắt Chức năng
CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition.
Post JB, Hami N, Mertens AEE, Elfrink S, Bos JL, Snippert HJG.
Oncotarget. 2019 Feb 15;10(14):1440-1457 | doi: 10.18632/oncotarget.26677 | PMID: 30858928 | PMC: PMC6402720
Tóm tắt Chức năng
Comparison of efficiency and time to regeneration of Agrobacterium-mediated transformation methods in Medicago truncatula.
Wen L, Chen Y, Schnabel E, Crook A, Frugoli J.
Plant methods. 2019;15:20 | doi: 10.1186/s13007-019-0404-1 | PMID: 30858871 | PMC: PMC6394069
Tóm tắt Chức năng
In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease.
Park H, Oh J, Shim G, Cho B, Chang Y, Kim S, Baek S, Kim H, Shin J, Choi H, Yoo J, Kim J, Jun W, Lee M, Lengner CJ, Oh YK, Kim J.
Nature neuroscience. 2019 Mar 11; | doi: 10.1038/s41593-019-0352-0 | PMID: 30858603
Tóm tắt Chức năng
Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation.
Howden SE, Vanslambrouck JM, Wilson SB, Tan KS, Little MH.
EMBO reports. 2019 Mar 11; | doi: 10.15252/embr.201847483 | PMID: 30858339
Tóm tắt Chức năng
The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity.
Masud HMAA, Watanabe T, Sato Y, Goshima F, Kimura H, Murata T.
Virology. 2019 Feb 23;531:114-125 | doi: 10.1016/j.virol.2019.02.015 | PMID: 30856483
Tóm tắt Chức năng
CRISPR-Cas in Streptococcus pyogenes.
Le Rhun A, Escalera-Maurer A, Bratovič M, Charpentier E.
RNA biology. 2019 Mar 11;:1-10 | doi: 10.1080/15476286.2019.1582974 | PMID: 30856357
Tóm tắt Chức năng
Development of CRISPR/Cas9-mediated gene disruption systems in Giardia lamblia.
Lin ZQ, Gan SW, Tung SY, Ho CC, Su LH, Sun CH.
PloS one. 2019;14(3):e0213594 | doi: 10.1371/journal.pone.0213594 | PMID: 30856211
Tóm tắt Chức năng
Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.
Peterka M, Kornmann B.
PLoS genetics. 2019 Mar 11;15(3):e1008050 | doi: 10.1371/journal.pgen.1008050 | PMID: 30856164
Tóm tắt Chức năng
CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells.
Min YL, Li H, Rodriguez-Caycedo C, Mireault AA, Huang J, Shelton JM, McAnally JR, Amoasii L, Mammen PPA, Bassel-Duby R, Olson EN.
Science advances. 2019 Mar;5(3):eaav4324 | doi: 10.1126/sciadv.aav4324 | PMID: 30854433 | PMC: PMC6402849
Tóm tắt Chức năng
Insights Into Non-coding RNAs as Novel Antimicrobial Drugs.
Parmeciano Di Noto G, Molina MC, Quiroga C.
Frontiers in genetics. 2019;10:57 | doi: 10.3389/fgene.2019.00057 | PMID: 30853970 | PMC: PMC6395445
Tóm tắt Chức năng
Gene Editing and Systems Biology Tools for Pesticide Bioremediation: A Review.
Jaiswal S, Singh DK, Shukla P.
Frontiers in microbiology. 2019;10:87 | doi: 10.3389/fmicb.2019.00087 | PMID: 30853940 | PMC: PMC6396717
Tóm tắt Chức năng
Age-related cardiopathies gene editing.
Song M, Belmonte JCI, Liu GH.
Aging. 2019 Mar 10;11(5):1327-1328 | doi: 10.18632/aging.101853 | PMID: 30853663
Tóm tắt Chức năng
Synthetic biology and metabolic engineering of actinomycetes for natural product discovery.
Palazzotto E, Tong Y, Lee SY, Weber T.
Biotechnology advances. 2019 Mar 7; | doi: 10.1016/j.biotechadv.2019.03.005 | PMID: 30853630
Tóm tắt Chức năng
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility.
Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, Ueda T, Gee P, Nishikawa M, Nomura M, Kitaoka F, Takahashi T, Okita K, Yoshida Y, Kaneko S, Hotta A.
Cell stem cell. 2019 Feb 28; | doi: 10.1016/j.stem.2019.02.005 | PMID: 30853558
Tóm tắt Chức năng
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ.
Molecular cell. 2019 Mar 6; | doi: 10.1016/j.molcel.2019.02.010 | PMID: 30853401
Tóm tắt Chức năng
Efficient Gene Editing at Major CFTR Mutation Loci.
Ruan J, Hirai H, Yang D, Ma L, Hou X, Jiang H, Wei H, Rajagopalan C, Mou H, Wang G, Zhang J, Li K, Chen YE, Sun F, Xu J.
Molecular therapy. Nucleic acids. 2019 Feb 16;16:73-81 | doi: 10.1016/j.omtn.2019.02.006 | PMID: 30852378
Tóm tắt Chức năng
Large-scale compound screens and pharmacogenomic interactions in cancer.
McDermott U.
Current opinion in genetics & development. 2019 Mar 7;54:12-16 | doi: 10.1016/j.gde.2019.02.002 | PMID: 30852338
Tóm tắt Chức năng
Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation.
Liao Y, Ouyang L, Ci L, Chen B, Lv D, Li Q, Sun Y, Fei J, Bao S, Liu X, Li L.
Biomaterials. 2019 Mar 1;203:12-22 | doi: 10.1016/j.biomaterials.2019.02.027 | PMID: 30851489
Tóm tắt Chức năng
Lysophosphatidylinositol-acyltrasferase-1 (LPIAT1) is involved in cytosolic Ca2+ oscillations in macrophages.
Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K.
Genes to cells : devoted to molecular & cellular mechanisms. 2019 Mar 9; | doi: 10.1111/gtc.12681 | PMID: 30851234
Tóm tắt Chức năng
Non-proteinaceous effectors: the terra incognita of plant-fungal interactions.
Collemare J, O'Connell R, Lebrun MH.
The New phytologist. 2019 Mar 9; | doi: 10.1111/nph.15785 | PMID: 30851201
Tóm tắt Chức năng
Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection.
Kaushik A, Yndart A, Atluri V, Tiwari S, Tomitaka A, Gupta P, Jayant RD, Alvarez-Carbonell D, Khalili K, Nair M.
Scientific reports. 2019 Mar 8;9(1):3928 | doi: 10.1038/s41598-019-40222-4 | PMID: 30850620
Tóm tắt Chức năng
CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.
Cullot G, Boutin J, Toutain J, Prat F, Pennamen P, Rooryck C, Teichmann M, Rousseau E, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Prouzet-Mauléon V, Turcq B, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A.
Nature communications. 2019 Mar 8;10(1):1136 | doi: 10.1038/s41467-019-09006-2 | PMID: 30850590 | PMC: PMC6408493
Tóm tắt Chức năng
Bub1-the zombie protein that CRISPR cannot kill.
Meraldi P.
The EMBO journal. 2019 Mar 8; | doi: 10.15252/embj.2019101912 | PMID: 30850387
Tóm tắt Chức năng
Accurate analysis of genuine CRISPR editing events with ampliCan.
Labun K, Guo X, Chavez A, Church G, Gagnon JA, Valen E.
Genome research. 2019 Mar 8; | doi: 10.1101/gr.244293.118 | PMID: 30850374
Tóm tắt Chức năng
Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
Zhu Y, Gao A, Zhan Q, Wang Y, Feng H, Liu S, Gao G, Serganov A, Gao P.
Molecular cell. 2019 Mar 5; | doi: 10.1016/j.molcel.2019.01.038 | PMID: 30850331
Tóm tắt Chức năng
CRISPR/Cas9: a powerful tool for identification of new targets for cancer treatment.
Liu B, Saber A, Haisma HJ.
Drug discovery today. 2019 Mar 5; | doi: 10.1016/j.drudis.2019.02.011 | PMID: 30849442
Tóm tắt Chức năng
Characterization of strain-specific phenotypes associated with knockout of dense granule protein 9 in Toxoplasma gondii.
Guo H, Gao Y, Jia H, Moumouni PFA, Masatani T, Liu M, Lee SH, Galon EM, Li J, Li Y, Tumwebaze MA, Benedicto B, Xuan X.
Molecular and biochemical parasitology. 2019 Mar 5; | doi: 10.1016/j.molbiopara.2019.01.003 | PMID: 30849416
Tóm tắt Chức năng
Public views about gene editing wildlife for conservation.
Kohl PA, Brossard D, Scheufele DA, Xenos MA.
Conservation biology : the journal of the Society for Conservation Biology. 2019 Mar 8; | doi: 10.1111/cobi.13310 | PMID: 30848502
Tóm tắt Chức năng
Disruption of CTLA-4 expression on peripheral blood CD8 + T cell enhances anti-tumor efficacy in bladder cancer.
Zhang W, Shi L, Zhao Z, Du P, Ye X, Li D, Cai Z, Han J, Cai J.
Cancer chemotherapy and pharmacology. 2019 Mar 8; | doi: 10.1007/s00280-019-03800-x | PMID: 30848330
Tóm tắt Chức năng
RNA-guided endonuclease - in situ labelling (RGEN-ISL): a fast CRISPR/Cas9-based method to label genomic sequences in various species.
Ishii T, Schubert V, Khosravi S, Dreissig S, Metje-Sprink J, Sprink T, Fuchs J, Meister A, Houben A.
The New phytologist. 2019 Mar 8; | doi: 10.1111/nph.15720 | PMID: 30847946
Tóm tắt Chức năng
Therapeutic Genome Editing in Cardiovascular Diseases.
German DM, Mitalipov S, Mishra A, Kaul S.
JACC. Basic to translational science. 2019 Feb;4(1):122-131 | doi: 10.1016/j.jacbts.2018.11.004 | PMID: 30847427 | PMC: PMC6390678
Tóm tắt Chức năng
Responsive Cells for rhEGF bioassay Obtained through Screening of a CRISPR/Cas9 Library.
Qin X, Yao W, Shi X, Liu L, Huang F, Ding Y, Zhou Y, Yu L, Jia C, Li S, Rao C, Wang J.
Scientific reports. 2019 Mar 7;9(1):3780 | doi: 10.1038/s41598-019-40381-4 | PMID: 30846752
Tóm tắt Chức năng
Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target.
Park SJ, Kim B, Choi S, Balasubramaniam S, Lee SC, Lee JY, Kim HS, Kim JY, Kim JJ, Lee YA, Kang NY, Kim JS, Chang YT.
Nature communications. 2019 Mar 7;10(1):1111 | doi: 10.1038/s41467-019-08990-9 | PMID: 30846702 | PMC: PMC6405920
Tóm tắt Chức năng
Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region.
Ma H, Tu LC, Chung YC, Naseri A, Grunwald D, Zhang S, Pederson T.
The Journal of cell biology. 2019 Mar 7; | doi: 10.1083/jcb.201807162 | PMID: 30846483
Tóm tắt Chức năng
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.
Kowalski PS, Rudra A, Miao L, Anderson DG.
Molecular therapy : the journal of the American Society of Gene Therapy. 2019 Feb 19; | doi: 10.1016/j.ymthe.2019.02.012 | PMID: 30846391
Tóm tắt Chức năng
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K.
Molecular cell. 2019 Feb 26; | doi: 10.1016/j.molcel.2019.01.037 | PMID: 30846317
Tóm tắt Chức năng
Improving CRISPR Genome Editing by Engineering Guide RNAs.
Moon SB, Kim DY, Ko JH, Kim JS, Kim YS.
Trends in biotechnology. 2019 Mar 4; | doi: 10.1016/j.tibtech.2019.01.009 | PMID: 30846198
Tóm tắt Chức năng
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW.
Journal of translational medicine. 2019 Mar 7;17(1):72 | doi: 10.1186/s12967-019-1820-8 | PMID: 30845965
Tóm tắt Chức năng
Efficient Genome Editing Using CRISPR/Cas9 Technology in Chicory.
Bernard G, Gagneul D, Alves Dos Santos H, Etienne A, Hilbert JL, Rambaud C.
International journal of molecular sciences. 2019 Mar 6;20(5) | doi: 10.3390/ijms20051155 | PMID: 30845784
Tóm tắt Chức năng
Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes.
Hundertmark T, Kreutz S, Merle N, Nist A, Lamp B, Stiewe T, Brehm A, Renkawitz-Pohl R, Rathke C.
PloS one. 2019;14(3):e0213177 | doi: 10.1371/journal.pone.0213177 | PMID: 30845228
Tóm tắt Chức năng
Edition of TFAM gene by CRISPR/Cas9 technology in bovine model.
de Oliveira VC, Moreira GSA, Bressan FF, Gomes Mariano Junior C, Roballo KCS, Charpentier M, Concordet JP, Meirelles FV, Ambrósio CE.
PloS one. 2019;14(3):e0213376 | doi: 10.1371/journal.pone.0213376 | PMID: 30845180
Tóm tắt Chức năng
Enhanced in vivo-imaging in medaka by optimized anaesthesia, fluorescent protein selection and removal of pigmentation.
Lischik CQ, Adelmann L, Wittbrodt J.
PloS one. 2019;14(3):e0212956 | doi: 10.1371/journal.pone.0212956 | PMID: 30845151
Tóm tắt Chức năng
Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.
Tabrizi SJ, Ghosh R, Leavitt BR.
Neuron. 2019 Mar 6;101(5):801-819 | doi: 10.1016/j.neuron.2019.01.039 | PMID: 30844400
Tóm tắt Chức năng
Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system.
Shi Z, Xin H, Tian D, Lian J, Wang J, Liu G, Ran R, Shi S, Zhang Z, Shi Y, Deng Y, Hou C, Chen Y.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Mar 7;:fj201802661R | doi: 10.1096/fj.201802661R | PMID: 30844313
Tóm tắt Chức năng
Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance.
Ko T, Li S.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Mar 7;:fj201801534RR | doi: 10.1096/fj.201801534RR | PMID: 30844312
Tóm tắt Chức năng
Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.
Tong SJ, Wall AA, Hung Y, Luo L, Stow JL.
Small GTPases. 2019 Mar 7;:1-17 | doi: 10.1080/21541248.2019.1587278 | PMID: 30843452
Tóm tắt Chức năng
Kidney Organoids in Translational Medicine: Disease Modeling and Regenerative Medicine.
Miyoshi T, Hiratsuka K, Garcia Saiz E, Morizane R.
Developmental dynamics : an official publication of the American Association of Anatomists. 2019 Mar 6; | doi: 10.1002/dvdy.22 | PMID: 30843293
Tóm tắt Chức năng
Combined Knockout of RIPK3 and MLKL Reveals Unexpected Outcome in Tissue Injury and Inflammation.
Moerke C, Bleibaum F, Kunzendorf U, Krautwald S.
Frontiers in cell and developmental biology. 2019;7:19 | doi: 10.3389/fcell.2019.00019 | PMID: 30842945 | PMC: PMC6391322
Tóm tắt Chức năng
An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors.
Rogers EJ, Jada R, Schragenheim-Rozales K, Sah M, Cortes M, Florence M, Levy NS, Moss R, Walikonis RS, Palty R, Shalgi R, Lichtman D, Kavushansky A, Gerges NZ, Kahn I, Umanah GKE, Levy AP.
Frontiers in molecular neuroscience. 2019;12:43 | doi: 10.3389/fnmol.2019.00043 | PMID: 30842726 | PMC: PMC6391579
Tóm tắt Chức năng
Tryptophan hydroxylase (TRH) loss of function mutations in Daphnia deregulated growth, energetic, serotoninergic and arachidonic acid metabolic signalling pathways.
Campos B, Rivetti C, Tauler R, Piña B, Barata C.
Scientific reports. 2019 Mar 6;9(1):3693 | doi: 10.1038/s41598-019-39987-5 | PMID: 30842467 | PMC: PMC6403212
Tóm tắt Chức năng
Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis.
Zhao L, Huang J, Fan Y, Li J, You T, He S, Xiao G, Chen D.
Annals of the rheumatic diseases. 2019 Mar 6; | doi: 10.1136/annrheumdis-2018-214724 | PMID: 30842121
Tóm tắt Chức năng
CRISPR-Cas13a Nanomachine Based Simple Technology for Avian Influenza A (H7N9) Virus On-Site Detection.
Liu Y, Xu H, Liu C, Peng L, Khan H, Cui L, Huang R, Wu C, Shen S, Wang S, Liang W, Li Z, Xu B, He N.
Journal of biomedical nanotechnology. 2019 Apr 1;15(4):790-798 | doi: 10.1166/jbn.2019.2742 | PMID: 30841971
Tóm tắt Chức năng
ZeoR: A Candidate for Assays Testing Enzymatic Activities and Off-Target Effects of Gene-Editing Enzymes.
Xu H, Luo D, Gao X, Liu X, Wang Q, Sun A, Shen J, He R, Lu G, Li K, Zhang J, Xiao L.
Journal of biomedical nanotechnology. 2019 Apr 1;15(4):662-673 | doi: 10.1166/jbn.2019.2720 | PMID: 30841961
Tóm tắt Chức năng
Genetic Dissection of the Type III-A CRISPR-Cas System Csm Complex Reveals Roles of Individual Subunits.
Mogila I, Kazlauskiene M, Valinskyte S, Tamulaitiene G, Tamulaitis G, Siksnys V.
Cell reports. 2019 Mar 5;26(10):2753-2765.e4 | doi: 10.1016/j.celrep.2019.02.029 | PMID: 30840895
Tóm tắt Chức năng
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.
Dupays L, Towers N, Wood S, David A, Stuckey DJ, Mohun T.
PloS one. 2019;14(3):e0212992 | doi: 10.1371/journal.pone.0212992 | PMID: 30840660
Tóm tắt Chức năng
netprioR: a probabilistic model for integrative hit prioritisation of genetic screens.
Schmich F, Kuipers J, Merdes G, Beerenwinkel N.
Statistical applications in genetics and molecular biology. 2019 Mar 6; | doi: 10.1515/sagmb-2018-0033 | PMID: 30840598
Tóm tắt Chức năng
Neuronal Apolipoprotein E4 increases cell death and p-tau release in Alzheimer's disease.
Wadhwani AR, Affaneh A, Van Gulden S, Kessler JA.
Annals of neurology. 2019 Mar 6; | doi: 10.1002/ana.25455 | PMID: 30840313
Tóm tắt Chức năng
Dek42 encodes an RNA binding protein that affects alternative pre-mRNA splicing and maize kernel development.
Zuo Y, Feng F, Qi W, Song R.
Journal of integrative plant biology. 2019 Mar 6; | doi: 10.1111/jipb.12798 | PMID: 30839161
Tóm tắt Chức năng
CRISPR/Cas9-mediated knockout of Ms1 enables the rapid generation of male-sterile hexaploid wheat lines for use in hybrid seed production.
Okada A, Arndell T, Borisjuk N, Sharma N, Watson-Haigh NS, Tucker EJ, Baumann U, Langridge P, Whitford R.
Plant biotechnology journal. 2019 Mar 6; | doi: 10.1111/pbi.13106 | PMID: 30839150
Tóm tắt Chức năng
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.
Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M.
eLife. 2019 Mar 6;8 | doi: 10.7554/eLife.42549 | PMID: 30838976
Tóm tắt Chức năng
One-Hit Wonders and 2-Hit Tubers: A Second-Hit to TSC2 Causes Tuber-Like Cells in Spheroids.
Goswami S, Hsieh J.
Epilepsy currents. 2019 Jan;19(1):49-50 | doi: 10.1177/1535759718822036 | PMID: 30838931
Tóm tắt Chức năng
Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells.
Wu M, Feng Y, Ye GX, Han YC, Wang SS, Ni HF, Wang FM, Gao M, Lv LL, Liu BC.
American journal of physiology. Renal physiology. 2019 Mar 6; | doi: 10.1152/ajprenal.00413.2018 | PMID: 30838870
Tóm tắt Chức năng
DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer.
Joshi RR, Ali SI, Ashley AK.
Journal of nucleic acids. 2019;2019:9170341 | doi: 10.1155/2019/9170341 | PMID: 30838131 | PMC: PMC6374816
Tóm tắt Chức năng
Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice.
Chao T, Liu Z, Zhang Y, Zhang L, Huang R, He L, Gu Y, Chen Z, Zheng Q, Shi L, Zheng W, Qi X, Kong E, Zhang Z, Lawrence T, Liang Y, Lu L.
Frontiers in genetics. 2019;10:124 | doi: 10.3389/fgene.2019.00124 | PMID: 30838037 | PMC: PMC6390232
Tóm tắt Chức năng
Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell Resistance.
Han P, Dai Q, Fan L, Lin H, Zhang X, Li F, Yang X.
Frontiers in immunology. 2019;10:251 | doi: 10.3389/fimmu.2019.00251 | PMID: 30837996 | PMC: PMC6389627
Tóm tắt Chức năng
Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in.
Rezza A, Jacquet C, Le Pillouer A, Lafarguette F, Ruptier C, Billandon M, Isnard Petit P, Trouttet S, Thiam K, Fraichard A, Chérifi Y.
Scientific reports. 2019 Mar 5;9(1):3486 | doi: 10.1038/s41598-019-40181-w | PMID: 30837594 | PMC: PMC6401152
Tóm tắt Chức năng
CRISPR/CAS9 targeted CAPTURE of mammalian genomic regions for characterization by NGS.
Slesarev A, Viswanathan L, Tang Y, Borgschulte T, Achtien K, Razafsky D, Onions D, Chang A, Cote C.
Scientific reports. 2019 Mar 5;9(1):3587 | doi: 10.1038/s41598-019-39667-4 | PMID: 30837529 | PMC: PMC6401131
Tóm tắt Chức năng
A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae.
Zhang Y, Wang J, Wang Z, Zhang Y, Shi S, Nielsen J, Liu Z.
Nature communications. 2019 Mar 5;10(1):1053 | doi: 10.1038/s41467-019-09005-3 | PMID: 30837474 | PMC: PMC6400946
Tóm tắt Chức năng
CRISPR Spacers Indicate Preferential Matching of Specific Virioplankton Genes.
Nasko DJ, Ferrell BD, Moore RM, Bhavsar JD, Polson SW, Wommack KE.
mBio. 2019 Mar 5;10(2) | doi: 10.1128/mBio.02651-18 | PMID: 30837341
Tóm tắt Chức năng
CRISPR/Cas9 Edited sRAGE-MSCs Protect Neuronal Death in Parkinson's Disease Model.
Lee J, Bayarsaikhan D, Arivazhagan R, Park H, Lim B, Gwak P, Jeong GB, Lee J, Byun K, Lee B.
International journal of stem cells. 2019 Feb 28; | doi: 10.15283/ijsc18110 | PMID: 30836725
Tóm tắt Chức năng
Glucose drives growth factor-independent esophageal cancer proliferation via phosphohistidine-FAK signaling.
Zhang J, Gelman IH, Katsuta E, Liang Y, Wang X, Li J, Qu J, Yan L, Takabe K, Hochwald SN.
Cellular and molecular gastroenterology and hepatology. 2019 Mar 2; | doi: 10.1016/j.jcmgh.2019.02.009 | PMID: 30836148
Tóm tắt Chức năng
Base editing the mammalian genome.
Schatoff EM, Zafra MP, Dow LE.
Methods (San Diego, Calif.). 2019 Mar 2; | doi: 10.1016/j.ymeth.2019.02.022 | PMID: 30836137
Tóm tắt Chức năng
Swift Large-scale Examination of Directed Genome Editing.
Hammouda OT, Böttger F, Wittbrodt J, Thumberger T.
PloS one. 2019;14(3):e0213317 | doi: 10.1371/journal.pone.0213317 | PMID: 30835740
Tóm tắt Chức năng
CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture.
Chen K, Wang Y, Zhang R, Zhang H, Gao C.
Annual review of plant biology. 2019 Mar 5; | doi: 10.1146/annurev-arplant-050718-100049 | PMID: 30835493
Tóm tắt Chức năng
Addiction systems antagonize bacterial adaptive immunity.
van Sluijs L, van Houte S, van der Oost J, Brouns SJJ, Buckling A, Westra ER.
FEMS microbiology letters. 2019 Mar 5; | doi: 10.1093/femsle/fnz047 | PMID: 30834930
Tóm tắt Chức năng
A singular system with precise dosing and spatiotemporal control of CRISPR-Cas9.
Choudhary A, Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law B, Mazitschek R.
Angewandte Chemie (International ed. in English). 2019 Mar 4; | doi: 10.1002/anie.201900788 | PMID: 30834641
Tóm tắt Chức năng
Pooled CRISPR/Cas9 reveals redundant roles of plastidial phosphoglycerate kinases in carbon fixation and metabolism.
Li R, Qiu Z, Wang X, Gong P, Xu Q, Yu QB, Guan Y.
The Plant journal : for cell and molecular biology. 2019 Mar 4; | doi: 10.1111/tpj.14303 | PMID: 30834637
Tóm tắt Chức năng
One-step genome editing of elite crop germplasm during haploid induction.
Kelliher T, Starr D, Su X, Tang G, Chen Z, Carter J, Wittich PE, Dong S, Green J, Burch E, McCuiston J, Gu W, Sun Y, Strebe T, Roberts J, Bate NJ, Que Q.
Nature biotechnology. 2019 Mar;37(3):287-292 | doi: 10.1038/s41587-019-0038-x | PMID: 30833776
Tóm tắt Chức năng
CRISPR target prediction remains blunt tool for clinical applications.
Hodgson J.
Nature biotechnology. 2019 Mar;37(3):204-205 | doi: 10.1038/s41587-019-0057-7 | PMID: 30833770
Tóm tắt Chức năng
Vertex ramps up CRISPR repair.
Nature biotechnology. 2019 Mar;37(3):205 | doi: 10.1038/s41587-019-0061-y | PMID: 30833766
Tóm tắt Chức năng
Target-dependent nickase activities of the CRISPR-Cas nucleases Cpf1 and Cas9.
Fu BXH, Smith JD, Fuchs RT, Mabuchi M, Curcuru J, Robb GB, Fire AZ.
Nature microbiology. 2019 Mar 4; | doi: 10.1038/s41564-019-0382-0 | PMID: 30833733
Tóm tắt Chức năng
Genome-wide target specificity of CRISPR RNA-guided adenine base editors.
Kim D, Kim DE, Lee G, Cho SI, Kim JS.
Nature biotechnology. 2019 Mar 4; | doi: 10.1038/s41587-019-0050-1 | PMID: 30833658
Tóm tắt Chức năng
Loss of trefoil factor 2 sensitizes rat pups to systemic infection with the neonatal pathogen Escherichia coli K1.
McCarthy AJ, Birchenough GMH, Taylor PW.
Infection and immunity. 2019 Mar 4; | doi: 10.1128/IAI.00878-18 | PMID: 30833331
Tóm tắt Chức năng
Neddylation inactivation facilitates FOXO3a nuclear export to suppress estrogen receptor transcription and improve fulvestrant sensitivity.
Jia X, Li C, Li L, Zhou L, Zhang W, Ni S, Lu Y, Chen L, Jeong LS, Yu J, Zhang Y, Zhang J, He S, Hu X, Sun H, Yu K, Liu G, Zhao H, Zhang Y, Jia L, Shao Z.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Mar 4; | doi: 10.1158/1078-0432.CCR-18-2434 | PMID: 30833270
Tóm tắt Chức năng
Intersex regulates female external genital and imaginal disc development in the silkworm.
Xu J, Yu Y, Chen K, Huang Y.
Insect biochemistry and molecular biology. 2019 Mar 1;108:1-8 | doi: 10.1016/j.ibmb.2019.02.003 | PMID: 30831220
Tóm tắt Chức năng
Acquired BRAF rearrangements induce secondary resistance to EGFR therapy in EGFR-mutated lung cancers.
Vojnic M, Kubota D, Kurzatkowski C, Offin M, Suzawa K, Benayed R, Schoenfeld AJ, Plodkowski AJ, Poirier JT, Rudin CM, Kris MG, Rosen NX, Yu HA, Riely GJ, Arcila ME, Somwar R, Ladanyi M.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Mar 1; | doi: 10.1016/j.jtho.2018.12.038 | PMID: 30831205
Tóm tắt Chức năng
Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9.
Takashima S, Shinkuma S, Fujita Y, Nomura T, Ujiie H, Natsuga K, Iwata H, Nakamura H, Vorobyev A, Abe R, Shimizu H.
The Journal of investigative dermatology. 2019 Mar 1; | doi: 10.1016/j.jid.2019.02.015 | PMID: 30831133
Tóm tắt Chức năng
Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion.
Isa NM, Zulkifli NA, Man S.
Science and engineering ethics. 2019 Mar 4; | doi: 10.1007/s11948-019-00098-z | PMID: 30830592
Tóm tắt Chức năng
Exome sequencing reveals POLR3H gene as a novel cause of Primary Ovarian Insufficiency.
Franca MM, Han X, Funari MFA, Lerario AM, Nishi MY, Fontenele EGP, Domenice S, Jorge AAL, Garcia-Galiano D, Elias CF, Mendonca BB.
The Journal of clinical endocrinology and metabolism. 2019 Mar 4; | doi: 10.1210/jc.2018-02485 | PMID: 30830215
Tóm tắt Chức năng
The zinc-finger transcription factor CcLOL1 controls chloroplast development and immature pepper fruit color in Capsicum chinense and its function is conserved in tomato.
Borovsky Y, Monsonego N, Mohan V, Shabtai S, Kamara I, Faigenboim A, Hill T, Chen S, Stoffel K, Van Deynze A, Paran I.
The Plant journal : for cell and molecular biology. 2019 Mar 3; | doi: 10.1111/tpj.14305 | PMID: 30828904
Tóm tắt Chức năng
CRISPR-Cas for Fungal Genome Editing: A New Tool for the Management of Plant Diseases.
Muñoz IV, Sarrocco S, Malfatti L, Baroncelli R, Vannacci G.
Frontiers in plant science. 2019;10:135 | doi: 10.3389/fpls.2019.00135 | PMID: 30828340 | PMC: PMC6384228
Tóm tắt Chức năng
Advances in CRISPR/Cas9 Technology for in Vivo Translation.
Çiçek YA, Luther DC, Kretzmann JA, Rotello VM.
Biological & pharmaceutical bulletin. 2019;42(3):304-311 | doi: 10.1248/bpb.b18-00811 | PMID: 30828060
Tóm tắt Chức năng
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening.
Esposito R, Bosch N, Lanzós A, Polidori T, Pulido-Quetglas C, Johnson R.
Cancer cell. 2019 Feb 14; | doi: 10.1016/j.ccell.2019.01.019 | PMID: 30827888
Tóm tắt Chức năng
SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation.
Calvo-Garrido J, Maffezzini C, Schober FA, Clemente P, Uhlin E, Kele M, Stranneheim H, Lesko N, Bruhn H, Svenningsson P, Falk A, Wedell A, Freyer C, Wredenberg A.
Stem cell reports. 2019 Feb 11; | doi: 10.1016/j.stemcr.2019.01.023 | PMID: 30827875
Tóm tắt Chức năng
Comparative study of commercially available and homemade anti-VAMP7 antibodies using CRISPR/Cas9-depleted HeLa cells and VAMP7 knockout mice.
Verraes A, Cholley B, Galli T, Nola S.
F1000Research. 2018;7:1649 | doi: 10.12688/f1000research.15707.2 | PMID: 30815249 | PMC: PMC6376254.2
Tóm tắt Chức năng
DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture.
Liu T, Wang J, Xie X, Wang K, Sui T, Liu D, Lai L, Zhao H, Li Z, Feng JQ.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2019 Mar 3; | doi: 10.1002/jbmr.3683 | PMID: 30827034
Tóm tắt Chức năng
The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J.
Toxicology letters. 2019 Mar 1;307:26-40 | doi: 10.1016/j.toxlet.2019.02.014 | PMID: 30826420
Tóm tắt Chức năng
The effect of LKB1 activity on the sensitivity to PI3K/mTOR inhibition in non-small cell lung cancer.
Shukuya T, Yamada T, Koenig MJ, Xu J, Okimoto T, Li F, Amann JM, Carbone DP.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Feb 27; | doi: 10.1016/j.jtho.2019.02.019 | PMID: 30825612
Tóm tắt Chức năng
Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation.
Kun RS, Gomes ACS, Hildén KS, Cerezo SS, Mäkelä MR, de Vries RP.
Biotechnology advances. 2019 Feb 27; | doi: 10.1016/j.biotechadv.2019.02.017 | PMID: 30825514
Tóm tắt Chức năng
The desirable donor pig to eliminate all xenoreactive antigens.
Ladowski J, Martens G, Estrada J, Tector M, Tector J.
Xenotransplantation. 2019 Mar 2;:e12504 | doi: 10.1111/xen.12504 | PMID: 30825348
Tóm tắt Chức năng
CRISPR restores expression in models of vision loss.
Cully M.
Nature reviews. Drug discovery. 2019 Mar;18(3):174 | doi: 10.1038/d41573-019-00016-9 | PMID: 30824889
Tóm tắt Chức năng
The proinflammatory cytokine TNF-α induces DNA demethylation-dependent and -independent activation of interleukin-32 expression.
Zhao Z, Lan M, Li J, Dong Q, Li X, Liu B, Li G, Wang H, Zhang Z, Zhu B.
The Journal of biological chemistry. 2019 Mar 1; | doi: 10.1074/jbc.RA118.006255 | PMID: 30824537
Tóm tắt Chức năng
Crosstalk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.
Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou M, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M.
The Journal of biological chemistry. 2019 Mar 1; | doi: 10.1074/jbc.RA118.006801 | PMID: 30824535
Tóm tắt Chức năng
OsNF-YC10, a seed preferentially expressed gene regulates grain width by affecting cell proliferation in rice.
Jia S, Xiong Y, Xiao P, Wang X, Yao J.
Plant science : an international journal of experimental plant biology. 2019 Mar;280:219-227 | doi: 10.1016/j.plantsci.2018.09.021 | PMID: 30824000
Tóm tắt Chức năng
CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool.
Loureiro A, da Silva GJ.
Antibiotics (Basel, Switzerland). 2019 Feb 28;8(1) | doi: 10.3390/antibiotics8010018 | PMID: 30823430
Tóm tắt Chức năng
CdpR Inhibits CRISPR-Cas Adaptive Immunity to Lower Anti-viral Defense while Avoiding Self-Reactivity.
Lin P, Pu Q, Shen G, Li R, Guo K, Zhou C, Liang H, Jiang J, Wu M.
iScience. 2019 Feb 15;13:55-68 | doi: 10.1016/j.isci.2019.02.005 | PMID: 30822746 | PMC: PMC6393702
Tóm tắt Chức năng
CRISPR links to long noncoding RNA function in mice: A practical approach.
Miano JM, Long X, Lyu Q.
Vascular pharmacology. 2019 Feb 27; | doi: 10.1016/j.vph.2019.02.004 | PMID: 30822570
Tóm tắt Chức năng
Site-specific integration of light chain and heavy chain genes of antibody into CHO-K1 stable hot spot and detection of antibody and fusion protein expression level.
Zhou S, Chen Y, Gong X, Jin J, Li H.
Preparative biochemistry & biotechnology. 2019 Mar 1;:1-7 | doi: 10.1080/10826068.2019.1573196 | PMID: 30822257
Tóm tắt Chức năng
Genome mutation after introduction of the gene editing by electroporation of Cas9 protein (GEEP) system in matured oocytes and putative zygotes.
Hirata M, Tanihara F, Wittayarat M, Hirano T, Nguyen NT, Le QA, Namula Z, Nii M, Otoi T.
In vitro cellular & developmental biology. Animal. 2019 Feb 28; | doi: 10.1007/s11626-019-00338-3 | PMID: 30820813
Tóm tắt Chức năng
Cell lineage inference from SNP and scRNA-Seq data.
Ding J, Lin C, Bar-Joseph Z.
Nucleic acids research. 2019 Mar 1; | doi: 10.1093/nar/gkz146 | PMID: 30820578
Tóm tắt Chức năng
CRISPRs for Strain Tracking and Their Application to Microbiota Transplantation Data Analysis.
Lam TJ, Ye Y.
The CRISPR journal. 2019 Feb 1;2(1):41-50 | doi: 10.1089/crispr.2018.0046 | PMID: 30820491 | PMC: PMC6390457
Tóm tắt Chức năng
CRISPR-PIN: Modifying gene position in the nucleus via dCas9-mediated tethering.
Lin JL, Ekas H, Deaner M, Alper HS.
Synthetic and systems biotechnology. 2019 Jun;4(2):73-78 | doi: 10.1016/j.synbio.2019.02.001 | PMID: 30820479 | PMC: PMC6378893
Tóm tắt Chức năng
Gene delivery methods and genome editing of human pluripotent stem cells.
Czerwińska P, Mazurek S, Kołodziejczak I, Wiznerowicz M.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 2019 Mar-Apr;24(2):180-187 | doi: 10.1016/j.rpor.2019.01.007 | PMID: 30820192 | PMC: PMC6379519
Tóm tắt Chức năng
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H.
Science (New York, N.Y.). 2019 Feb 28; | doi: 10.1126/science.aav9973 | PMID: 30819928
Tóm tắt Chức năng
A functional landscape of resistance to MEK1/2 and CDK4/6 inhibition in NRAS mutant melanoma.
Hayes TK, Luo F, Cohen O, Goodale AB, Lee Y, Pantel S, Bagul M, Piccioni F, Root DE, Garraway LA, Meyerson M, Johannessen CM.
Cancer research. 2019 Feb 28; | doi: 10.1158/0008-5472.CAN-18-2711 | PMID: 30819666
Tóm tắt Chức năng
Efficient introduction of an isogenic homozygous mutation to induced pluripotent stem cells from a hereditary hearing loss family using CRISPR/Cas9 and single-stranded donor oligonucleotides.
Dong Y, Peng T, Wu W, Tan D, Liu X, Xie D.
The Journal of international medical research. 2019 Feb 28;:300060519829990 | doi: 10.1177/0300060519829990 | PMID: 30819013
Tóm tắt Chức năng
Discussion: CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.
Sabol RA, Bunnell BA.
Plastic and reconstructive surgery. 2019 Mar;143(3):757-758 | doi: 10.1097/PRS.0000000000005391 | PMID: 30817647
Tóm tắt Chức năng
Xin vui lòng đăng nhập hoặc đăng ký tài khoản để có thể lưu các bài báo vào thư viện cá nhân

“Khoa học” được định nghĩa là “những tri thức đạt được qua kinh nghiệm thực tế và nghiên cứu”.

Webter’s New Collegiste Dictionary